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[1] [2] [3] [4] [5] … [11]

1. Effects of Mannich bases on cellular glutathione and related enzymes of Jurkat cells in culture conditions. Gul, M.; Gul, H.I.; Hänninen, O. Toxicology in Vitro vol. 16 issue 2 April, 2002. p. 107-112

 Jurkat cells were exposed to representative acetophenone-derived mono Mannich bases 2… (more)

Keywords: Mannich base

ISSN: 0887-2333.

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2. Biocidal activity of some Mannich base cationic derivatives. Negm, Nabel A.; Morsy, Salwa M.I.; Said, Medhat M. Bioorganic & Medicinal Chemistry vol. 13 issue 21 November 1, 2005. p. 5921-5926

 A novel series of cationic surfactants was prepared based on Mannich (more)

Keywords: Mannich base

DOI: 10.1016/j.bmc.2005.07.031. ISSN: 0968-0896.

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3. Prodrugs for dermal delivery. Sloan, K.B. Advanced Drug Delivery Reviews vol. 3 issue 1 January - February, 1989. p. 67-101

 The recent review by J. Hadgraft (1985, Prodrugs and skin absorption. In: H.… (more)

Keywords: N-Mannich base prodrug

DOI: 10.1016/0169-409X(89)90005-7. ISSN: 0169-409X.

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4. Dimethyl secondary amine chain extenders: a conceptual approach to in situ generation of advanced epoxy resins for rapid cure, low VOC coatings. Walker, Frederick H.; Cook, Michael; Vedage, Gamini; Rasing, Rob. Journal of Coatings Technology and Research vol. 6 issue 3 September 2009. p. 283 - 313

  Solid epoxy resin oligomers have traditionally been utilized for coatings that combine… (more)

Keywords: Mannich base

DOI: 10.1007/s11998-009-9178-0. ISSN: 1547-0091.

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5. The effects of some Mannich bases on heat shock proteins HSC70 and GRP75, and thioredoxin and glutaredoxin levels in Jurkat cells. Gul, Mustafa; Atalay, Mustafa; Gul, Halise Inci; Nakao, Chitose; Lappalainen, Jani; Hänninen, Osmo. Toxicology in Vitro vol. 19 issue 5 August, 2005. p. 573-580

Mannich bases interact with cellular thiols and inactivate thioredoxin reductase. In… (more)

Keywords: Mannich bases

DOI: 10.1016/j.tiv.2005.03.004. ISSN: 0887-2333.

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6. Imino- and aminomethylphenylboronic acids: stabilizing effect of hydrogen bonds. Adamczyk-Woźniak, Agnieszka; Cyrański, Michał K.; Frączak, Beata T.; Lewandowska, Agnieszka; Madura, Izabela D.; Sporzyński, Andrzej. Tetrahedron vol. 68 issue 19 May 13, 2012. p. 3761-3767

 ortho-Iminomethylphenylboronic acids were synthesized from the reaction of 2-formyl–phenylboronic acid with primary aromatic… (more)

Keywords: Mannich bases

DOI: 10.1016/j.tet.2012.02.072. ISSN: 0040-4020.

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7. One-pot synthesis and cytotoxicity studies of new Mannich base derivatives of polyether antibiotic—Lasalocid acid. Huczyński, Adam; Rutkowski, Jacek; Borowicz, Izabela; Wietrzyk, Joanna; Maj, Ewa; Brzezinski, Bogumil. Bioorganic & Medicinal Chemistry Letters vol. 23 issue 18 September 15, 2013. p. 5053-5056

 Seven Mannich base derivatives of polyether antibiotic Lasalocid acid (2a–2g) were… (more)

Keywords: Mannich bases synthesis

DOI: 10.1016/j.bmcl.2013.07.040. ISSN: 0960-894X.

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8. Reactions of nitrogenous derivatives of substituted salicylaldehydes with cyclic ketones and enamines. Ukhin, L. Yu.; Belousova, L. V.; Orlova, Zh. I.; Shishkina, S. V.; Shishkin, O. V. Russian Chemical Bulletin vol. 51 issue 7 July 2002. p. 1262-1269

 The reactions of aminals, the Mannich bases, and azomethines derived from… (more)

Keywords: Mannich bases

ISSN: 1066-5285.

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9. Synthesis of Novel Nalidixic Acid-Based 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Derivatives as Potent Antibacterial Agents. Aggarwal, Nisha; Kumar, Rajesh; Dureja, Prem; Khurana, Jitender Mohan. Chemical Biology & Drug Design vol. 79 issue 4 April 2012. p. 384-397

  Novel nalidixic acid-based 1,3,4-thia(oxa)diazoles, their thio ethers, sulfones, bis mercapto, and (more)

Keywords: Mannich bases

DOI: 10.1111/j.1747-0285.2011.01316.x. ISSN: 1747-0277.

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10. Synthesis and characterization of cobalt and nickel chelates of 5-dimethylaminomethyl-2-thiouracil and their evaluation as antimicrobial and anticancer agents. Kamalakannan, P.; Venkappayya, D. Journal of Inorganic Biochemistry vol. 90 issue 1-2 May 21, 2002. p. 22-37

 A new antimetabolite of adenine, viz. 5-dimethylaminomethyl-2-thiouracil, was synthesized using the Mannich reaction.… (more)

Keywords: Mannich base

ISSN: 0162-0134.

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11. Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. Chiyanzu, Idan; Clarkson, Cailean; Smith, Peter J.; Lehman, Julie; Gut, Jiri; Rosenthal, Philip J.; Chibale, Kelly. Bioorganic and Medicinal Chemistry vol. 13 issue 9 May 2, 2005. p. 3249-3261

 A new class of 4-aminoquinoline derivatives based on the natural product isatin scaffold… (more)

Keywords: Mannich bases

DOI: 10.1016/j.bmc.2005.02.037. ISSN: 0968-0896.

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12. Mannich-Type Reactions of Nitrones, Oximes, and Hydrazones. Merino, Pedro; Tejero, Tomás. Synlett vol. 2011 issue 14 2011. p. 1965-1977

Mannich-type reactions with nitrones, oximes, and hydrazones provide efficient approaches to β-amino carbonyl… (more)

Keywords: Mannich bases; nitrones; hydrazones; oximes; nucleophilic addition; hydroxylamines; hydrazines

DOI: 10.1055/s-0030-1260979. ISSN: 0936-5214.

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13. A New Efficient Synthesis of Spirocyclic Benzopyrans. Guillaumet, Gérald; Pavé, Grégoire; Chalard, Pierre; Viaud-Massuard, Marie-Claude; Troin, Yves. Synthesis vol. 2004 issue 1 January 2004.

Starting from a protected β-amino ketone and several 3-chromanones, spirocyclic benzopyran derivatives were obtained via a Mannich type condensation

Keywords: spiro compounds; heterocycles; protecting groups; ketones; chromanones; Mannich bases; condensation

DOI: 10.1055/s-2003-44353. ISSN: 0039-7881.

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14. Antiviral activity of indole derivatives. Giampieri, Michele; Balbi, Alessandro; Mazzei, Mauro; La Colla, Paolo; Ibba, Cristina; Loddo, Roberta. Antiviral Research vol. 83 issue 2 August, 2009. p. 179-185

 Unsymmetrical methylene derivatives 5 were prepared following a known method, by reaction of… (more)

Keywords: Mannich bases

DOI: 10.1016/j.antiviral.2009.05.001. ISSN: 0166-3542.

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15. In vitro study of some medicinally important Mannich bases derived from antitubercular agent. Joshi, Sheela; Khosla, Navita; Tiwari, Prapti. Bioorganic and Medicinal Chemistry vol. 12 issue 3 February 1, 2004. p. 571-576

 Biologically active Mannich bases with heteroaromatic ring system have been synthesised… (more)

Keywords: Mannich bases

DOI: 10.1016/j.bmc.2003.11.001. ISSN: 0968-0896.

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16. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one. Pandeya, S.N.; Sriram, D.; Nath, G.; De Clercq, E. Pharmaceutica Acta Helvetiae vol. 74 issue 1 December, 1999. p. 11-17

 Isatin (Indole 2,3-dione), its 5-chloro and 5-bromo derivatives were added to 3-amino-2-methylmercapto quinazolin-4(3H)-one… (more)

Keywords: Mannich bases

ISSN: 0031-6865.

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17. Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells. Gul, H. Inci; Vepsalainen, Jouko; Gul, Mustafa; Erciyas, Ercin; Hanninen, Osmo. Pharmaceutica Acta Helvetiae vol. 74 issue 4 April, 2000. p. 393-398

Mannich bases of acetophenones have been disclosed to have antitumour and… (more)

Keywords: Mannich bases

ISSN: 0031-6865.

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18. The Vinylogous Mannich Reaction: An Efficient Access to Substituted Nicotinonitriles. Risch, Nikolaus; Winter, Andreas. Synlett vol. 2003 issue 13 2003.

 A straightforward method for the preparation of substituted nicotinonitriles has been developed. Starting… (more)

Keywords: domino reactions; iminium salts; Mannich bases; β-enaminonitriles; nicotinonitriles; pyrroles; pyridines

DOI: 10.1055/s-2003-42044. ISSN: 0936-5214.

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19. The Vinylogous Mannich Reaction: An Efficient Access to Substituted Nicotinonitriles. Risch, Nikolaus; Winter, Andreas. Synlett vol. 2003 issue 13 2003. p. 1959-1964

 A straightforward method for the preparation of substituted nicotinonitriles has been developed. Starting… (more)

Keywords: domino reactions; iminium salts; Mannich bases; β-enaminonitriles; nicotinonitriles; pyrroles; pyridines

DOI: 10.1055/s-2003-42044. ISSN: 0936-5214.

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20. peri-Naphthylenediamines. 35. Unusual behavior of “proton sponge”-derived Mannich bases. Vinogradova, O. V.; Pozharskii, A. F.; Starikova, Z. A. Russian Chemical Bulletin vol. 52 issue 1 January 2003. p. 208-217

 Aminomethylation of 1,8-bis(dimethylamino)naphthalene (“proton sponge”) afforded a series of its 4-dialkylaminomethyl-substituted derivatives. An… (more)

Keywords: Mannich bases

ISSN: 1066-5285.

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21. Synthesis, characterization of Mannich base oligomers used with epoxy resin for glass fibre-reinforced laminates. Raj, M. M.; Raj, L. M.; Shah, T. B.; Patel, P. M. Journal of Thermal Analysis and Calorimetry vol. 101 issue 3 September 2010. p. 1003 - 1009

  This article aims to modify conventional epoxy resin by blending with four… (more)

Keywords: Mannich base

DOI: 10.1007/s10973-009-0591-5. ISSN: 1388-6150.

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22. LiClO4-Induced Mannich Reaction − Diastereo- and Enantioselective Synthesis of β-Amino Ketones by Addition of Enamines, Imines or Silylenolethers to Aldehydes and Dialkyltrimethylsilylamines. Zarghi, Afshin; Naimi-Jamal, M. Reza; Webb, Sarah A.; Balalaie, Said; Saidi, M. Reza; Ipaktschi, Junes. European Journal of Organic Chemistry vol. 1998 issue 1 January 1998. p. 197 - 200

 LiClO4-mediated one-pot reactions of aldehydes with (trimethylsilyl)dialkylamines 2, 5 or 19 and C… (more)

Keywords: Mannich bases

DOI: 10.1002/1099-0690(199801)1998:1<197::AID-EJOC197>3.0.CO;2-R. ISSN: 1434-193X.

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23. Pronounced Catalytic Effect of a Micellar Solution of Sodium Dodecylsulfate (SDS) Upon a Three-Component Reaction of Aldehydes, Amines, and Ketones Under Neutral Conditions. Jafari, Abbas Ali; Moradgholi, Fatemeh; Tamaddon, Fatemeh. European Journal of Organic Chemistry vol. 2009 issue 8 March 2009. p. 1249 - 1255

 A micellar solution of anionic, cationic or neutral surfactants can be used as… (more)

Keywords: Mannich bases

DOI: 10.1002/ejoc.200801037. ISSN: 1434-193X.

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24. NMR analysis, protonation equilibria and decomposition kinetics of tolperisone. Orgován, Gábor; Tihanyi, Károly; Noszál, Béla. Journal of Pharmaceutical and Biomedical Analysis vol. 50 issue 5 December 5, 2009. p. 718-723

 The rate constants of spontaneous and hydroxide-catalyzed decomposition and the tautomer-specific protonation constants… (more)

Keywords: Mannich base

DOI: 10.1016/j.jpba.2009.05.036. ISSN: 0731-7085.

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25. Mannich bases of phenolic azobenzenes possessing cytotoxic activity. Dimmock, JR; Erciyas, E; Kumar, P; Hetherington, M; Quail, JW; Pugazhenthi, U; Arpin, SA; Hayes, SJ; et al. European Journal of Medicinal Chemistry vol. 32 issue 7-8 July - August, 1997. p. 583-594

 A number of arylazophenols 1 were converted into the corresponding mono Mannich(more)

Keywords: Mannich base

ISSN: 0223-5234.

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26. A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities. Aytemir, Mutlu Dilsiz; Özçelik, Berrin. European Journal of Medicinal Chemistry vol. 45 issue 9 September, 2010. p. 4089-4095

 A series of 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives were synthesized and tested for their antimicrobial… (more)

Keywords: Mannich bases

DOI: 10.1016/j.ejmech.2010.05.069. ISSN: 0223-5234.

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27. Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. Suresh Kumar, G.V.; Rajendra Prasad, Y.; Mallikarjuna, B.P.; Chandrashekar, S.M. European Journal of Medicinal Chemistry vol. 45 issue 11 November, 2010. p. 5120-5129

 A series of novel clubbed Isopropylthiazole derivatives triazolothiadiazines 2a–g, dihydro triazolothiadiazoles 3a–g, thioxotriazoles… (more)

Keywords: Mannich bases

DOI: 10.1016/j.ejmech.2010.08.023. ISSN: 0223-5234.

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28. Novel Sources of Anthelmintics. Bennet-Jenkins, Eva; Bryant, C. International Journal for Parasitology vol. 26 issue 8-9 August - September, 1996. p. 937-950

 The G-series of naturally occurring compounds from Eucalyptus species contain representatives that are… (more)

Keywords: Mannich bases

ISSN: 0020-7519.

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29. Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide. Pandeya, S.N.; Sriram, D.; Nath, G.; DeClercq, E. European Journal of Pharmaceutical Sciences vol. 9 issue 1 October, 1999. p. 25-31

 Isatin, its 5-chloro and 5-bromo derivatives have been reacted with N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide to… (more)

Keywords: Mannich bases

ISSN: 0928-0987.

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30. Asymmetric Mannich Reactions by α-Silyl Controlled Aminomethylation of Ketones. Dieter; Johannes; Stefan; David. Synthesis vol. 2002 issue 18 December 2002. p. 2737-2748

 An efficient, regio- and enantioselective synthesis of α-substituted β-amino ketones has been developed.… (more)

Keywords: asymmetric synthesis; aminomethylation; ketones; enols; silicon; Mannich bases

DOI: 10.1055/s-2002-35998. ISSN: 0039-7881.

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[1] [2] [3] [4] [5] … [11]