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1. In vivo monitoring of extracellular 13N-glutamine derived from blood-borne 13N-ammonia in rat striatum using microdialysis with radio-LC method. Okada, Maki; Nakao, Ryuji; Hosoi, Rie; Zhang, Ming-Rong; Fukumura, Toshimitsu; Suzuki, Kazutoshi; Inoue, Osamu. Journal of Neuroscience Methods vol. 184 issue 1 October 30, 2009. p. 37-41

 Glutamine synthetase (GS) is selectively localized in astrocytes and has important roles in… (more)

Keywords: Microdialysis; β+ Detection; Astrocyte; 13N-ammonia; 13N-glutamine; Glutamine synthetase

DOI: 10.1016/j.jneumeth.2009.07.012. ISSN: 0165-0270.

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2. Repair of DNA Damage Induced by Accelerated Heavy Ions in Mammalian Cells Proficient and Deficient in the Non-homologous End-Joining Pathway. Okayasu, Ryuichi; Okada, Maki; Okabe, Atsushi; Noguchi, Miho; Takakura, Kaoru; Takahashi, Sentaro. Radiation Research vol. 165 issue 1 January 1, 2006. p. 59-67

  Okayasu, R., Okada, M., Okabe, A., Noguchi, M., Takakura, K. and Takahashi,… (more)

DOI: 10.1043/0033-7587(2006)165[0059:RODDIB]2.0.CO;2. ISSN: 0033-7587.

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3. Efficient synthesis and chiral separation of 11C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography. Kikuchi, Tatsuya; Okada, Maki; Nengaki, Nobuki; Furutsuka, Kenji; Wakizaka, Hidekatsu; Okamura, Toshimitsu; Zhang, Ming-Rong; Kato, Koichi. Bioorganic & Medicinal Chemistry vol. 19 issue 10 May 15, 2011. p. 3265-3273

 The pharmacological mechanisms focusing on chiral isomer of ibuprofen are not fully understood.… (more)

Keywords: NSAID; non-steroidal anti-inflammatory drug; COX; cyclooxygenase; PET; positron emission tomography; ee; enantiomeric excess; Radiolabeling; Radiolysis; DMSO; Chirality; NSAIDs; Ibuprofen

DOI: 10.1016/j.bmc.2011.03.041. ISSN: 0968-0896.

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4. Feasibility studies of 4′-[methyl-11C]thiothymidine as a tumor proliferation imaging agent in mice. Toyohara, Jun; Okada, Maki; Toramatsu, Chie; Suzuki, Kazutoshi; Irie, Toshiaki. Nuclear Medicine and Biology vol. 35 issue 1 January, 2008. p. 67-74

 This study reports on the radiosynthesis and feasibility studies of 4′-[methyl-11C]thiothymidine ([methyl-11C]S-dThd) as… (more)

Keywords: 11C; DNA synthesis; S-dThd; Proliferation; Tumor; PET

DOI: 10.1016/j.nucmedbio.2007.10.001. ISSN: 0969-8051.

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5. Transfer of maternally administered fusogenic liposome-DNA complexes into monkey fetuses in a pregnancy model. Hirano, Makoto; Nakamura, Shin; Mitsunaga, Fusako; Okada, Maki; Shimuzu, Keiko; Imamura, Takahisa. The Journal of Gene Medicine vol. 4 issue 5 September/October 2002. p. 560 - 566

 Materno-fetal transfer of intravenously administered liposome-plasmid DNA complexes has been demonstrated only in… (more)

Keywords: materno-fetal transfer; primate model; common marmoset; pregnant; liposome; GFP

DOI: 10.1002/jgm.289. ISSN: 1099-498X.

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6. High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells. Sekine, Emiko; Okada, Maki; Matsufuji, Naruhiro; Yu, Dong; Furusawa, Yoshiya; Okayasu, Ryuichi. Mut.Res.-Genetic Toxicology and Environmental Mutagenesis vol. 652 issue 1 March 29, 2008. p. 95-101

 We investigated the earliest possible chromosome break and repair process in normal human… (more)

Keywords: High LET radiation; Chromosome repair; Non-homologous end joining (NHEJ); Premature chromosome condensation (PCC); DNA double strand break (DSB); Wortmannin (WM)

DOI: 10.1016/j.mrgentox.2008.01.003. ISSN: 1383-5718.

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7. Facilitated detection of chromosome break and repair at low levels of ionizing radiation by addition of wortmannin to G1-type PCC fusion incubation. Okada, Maki; Saito, Shiori; Okayasu, Ryuichi. Mutation Research/Genetic Toxicology and Environmental Mutagenesis vol. 562 issue 1-2 August 8, 2004. p. 11-17

 We have measured rejoining kinetics of chromosome breaks using a modified cell fusion-based… (more)

Keywords: Radiation; Repair; Premature chromosome condensation (PCC); DNA double strand break; Wortmannin

DOI: 10.1016/j.mrgentox.2004.04.004. ISSN: 1383-5718.

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8. Combining high-performance liquid chromatography-positron detection and on-line microdialysis for animal metabolism study of positron emission tomography probes. Nakao, Ryuji; Okada, Maki; Inoue, Osamu; Fukumura, Toshimitsu; Suzuki, Kazutoshi. Journal of Chromatography A vol. 1203 issue 2 September 5, 2008. p. 193-197

 Automated ultra-performance liquid chromatography (LC) with a radiometric detection system has been developed… (more)

Keywords: Microdialysis; β+ detection; On-line sampling; PET probe; l-[β-11C]DOPA

DOI: 10.1016/j.chroma.2008.07.049. ISSN: 0021-9673.

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9. An Active-Site Mutation Causes Enhanced Reactivity and Altered Regiospecificity of Transglucosylation Catalyzed by the Bacillus sp. SAM1606 α-Glucosidase. Inohara-Ochiai, Misa; Okada, Maki; Nakayama, Toru; Hemmi, Hisashi; Ueda, Takashi; Iwashita, Takashi; Kan, Yukiko; Shibano, Yuji; Ashikari, Toshihiko; Nishino, Tokuzo. Journal of Bioscience and Bioengineering vol. 89 issue 5 2000. p. 431-437

 Bacillus sp. SAM1606 α-glucosidase catalyzes the transglucosylation of sucrose to produce three regioisomers… (more)

Keywords: α-glucosidase; transglucosylation; regiospecificity; α-amylase family; Bacillus

ISSN: 1389-1723.

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10. Site-specific mutagenesis at positions 272 and 273 of the Bacillus sp. SAM1606 α-glucosidase to screen mutants with altered specificity for oligosaccharide production by transglucosylation. Okada, Maki; Nakayama, Toru; Noguchi, Akio; Yano, Masayasu; Hemmi, Hisashi; Nishino, Tokuzo; Ueda, Takashi. Journal of Molecular Catalysis B: Enzymatic vol. 16 issue 5-6 February 18, 2002. p. 265-274

 The Bacillus sp. SAM1606 α-glucosidase catalyzes the transglucosylation of sucrose to produce theanderose… (more)

Keywords: Transglucosylation; Mutagenesis; Oligosaccharide; α-glucosidase; Theanderose

ISSN: 1381-1177.

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11. Deciphering the Molecular Basis of the Broad Substrate Specificity of α-Glucosidase from Bacillus sp. SAM1606. Noguchi, Akio; Yano, Masayasu; Ohshima, Yasuhiro; Hemmi, Hisashi; Inohara-Ochiai, Misa; Okada, Maki; Min, Kyong-Son; Nakayama, Toru; Nishino, Tokuzo. The Journal of Biochemistry vol. 134 issue 4 October 2003. p. 543-550

  The α-glucosidase of Bacillus sp. strain SAM1606 is a member of glycosyl… (more)

DOI: 10.1093/jb/mvg172. ISSN: 0021-924X.

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12. Efficacy of a B virus gD DNA vaccine for induction of humoral and cellular immune responses in Japanese macaques. Hirano, Makoto; Nakamura, Shin; Mitsunaga, Fusako; Okada, Maki; Shimizu, Keiko; Ueda, Masahiro; Bennett, Alice; Eberle, Richard. Vaccine vol. 20 issue 19-20 June 7, 2002. p. 2523-2532

 It is desirable to prevent dissemination of B virus (BV) in macaque colonies… (more)

Keywords: Cercopithecine herpesvirus 1; Glycoprotein D; DNA vaccine; Macaca fuscata

ISSN: 0264-410X.

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13. In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats. Yanamoto, Kazuhiko; Zhang, Ming-Rong; Kumata, Katsushi; Hatori, Akiko; Okada, Maki; Suzuki, Kazutoshi. Neuroscience Letters vol. 428 issue 2-3 November 27, 2007. p. 59-63

 AC-5216 was reported as a novel ligand for peripheral-type benzodiazepine receptor (PBR) with… (more)

Keywords: [11C]AC-5216; Peripheral-type benzodiazepine receptor; Neuroinflammation; Autoradiography

DOI: 10.1016/j.neulet.2007.09.050. ISSN: 0304-3940.

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14. Exercise Recommendations for Childhood Cancer Survivors Exposed to Cardiotoxic Therapies: An Institutional Clinical Practice Initiative. Okada, Maki; Meeske, Kathleen A.; Menteer, Jondavid; Freyer, David R. Journal of Pediatric Oncology Nursing vol. 29 issue 5 September 2012. p. 246-252

 Childhood cancer survivors who have received treatment with anthracyclines are at risk for… (more)

Keywords: anthracycline; cardiomyopathy; cancer survivorship; pediatric oncology; exercise

DOI: 10.1177/1043454212451525. ISSN: 1043-4542.

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15. Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-11C]acetate. Okada, Maki; Nakao, Ryuji; Momosaki, Sotaro; Yanamoto, Kazuhiko; Kikuchi, Tatsuya; Okamura, Toshimitsu; Wakizaka, Hidekatsu; Hosoi, Rie; Zhang, Ming-Rong; Inoue, Osamu. Applied Radiation and Isotopes vol. 78 August, 2013. p. 102-107

 Brain uptake of acetate is insufficient for obtaining a quantitative image of astrocytic… (more)

Keywords: [1-11C]acetate; Benzyl[11C]acetate; Positron emission tomography; Astrocyte; Energy metabolism

DOI: 10.1016/j.apradiso.2013.04.025. ISSN: 0969-8043.

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16. Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET. Galante, Eva; Okamura, Toshimitsu; Sander, Kerstin; Kikuchi, Tatsuya; Okada, Maki; Zhang, Ming-Rong; Robson, Mathew; Badar, Adam; Lythgoe, Mark; Koepp, Matthias; Arstad, Erik. Journal of Medicinal Chemistry [pre-publication article – no volume, issue, or page numbers in this version]

 Multidrug resistance-associated protein 1 (MRP1) is a drug efflux transporter that has been… (more)

DOI: 10.1021/jm401764a. ISSN: 0022-2623.

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17. Development of Purine-Derived 18F-Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET. Galante, Eva; Okamura, Toshimitsu; Sander, Kerstin; Kikuchi, Tatsuya; Okada, Maki; Zhang, Ming-Rong; Robson, Mathew; Badar, Adam; Lythgoe, Mark; Koepp, Matthias; Årstad, Erik. Journal of Medicinal Chemistry [pre-publication article – no volume, issue, or page numbers in this version]

 Multidrug resistance-associated protein 1 (MRP1) is a drug efflux transporter that has been… (more)

DOI: 10.1021/jm401764a. ISSN: 0022-2623.

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18. Development of Purine-Derived 18F-Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET. Galante, Eva; Okamura, Toshimitsu; Sander, Kerstin; Kikuchi, Tatsuya; Okada, Maki; Zhang, Ming-Rong; Robson, Mathew; Badar, Adam; Lythgoe, Mark; Koepp, Matthias; Årstad, Erik. Journal of Medicinal Chemistry vol. 57 issue 3 February 13, 2014. p. 1023-1032

 Multidrug resistance-associated protein 1 (MRP1) is a drug efflux transporter that has been… (more)

DOI: 10.1021/jm401764a. ISSN: 0022-2623.

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