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127 matches in the database. These are records: 31 - 60. New search.

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31. Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors. Maurel-Remy, S.; Bervoets, K.; Millan, Mark J. European Journal of Pharmacology vol. 280 issue 2 July 4, 1995. p. R9-R11

 Whereas haloperidol more potently blocked the locomotion elicited by amphetamine (2.5 mg/kg i.p.)… (more)

Keywords: 5-HT2A receptor; Phencyclidine; Clozapine

ISSN: 0014-2999.

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32. Activation of dopamine D3 autoreceptors inhibits firing of ventral tegmental dopaminergic neurones in vivo. Lejeune, Françoise; Millan, Mark J. European Journal of Pharmacology vol. 275 issue 3 March 14, 1995. p. R7-R9

 The firing rate of dopaminergic neurones in the ventral tegmental area of anaesthetised… (more)

Keywords: Dopamine D3 receptor; Ventral tegmental area; Dopamine

ISSN: 0014-2999.

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33. S 15535 and WAY 100,635 antagonise 5-HT-stimulated [35S]GTPγS binding at cloned human 5-HT1A receptors. Newman-Tancredi, Adrian; Chaput, Christine; Verrièle, Laurence; Millan, Mark J. European Journal of Pharmacology vol. 307 issue 1 June 20, 1996. p. 107-111

 In Chinese hamster ovary (CHO) cells expressing cloned human 5-HT1A receptors, S 15535… (more)

Keywords: S 15535; WAY 100,635; (±)-8-OH-DPAT ((±)-hydroxy-2-(di-n-propylamino)tetralin); 5-HT1A; [35S]GTPγS binding

ISSN: 0014-2999.

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34. The role of monoamines in the actions of established and “novel” antidepressant agents: a critical review. Millan, Mark J. European Journal of Pharmacology vol. 500 issue 1-3 October 1, 2004. p. 371-384

 Monoaminergic pathways are highly responsive to aversive stimuli and play a crucial role… (more)

Keywords: Depression; Antidepressant; Monoamine; Neurogenesis; SSRI; Tricyclic; Dopamine

DOI: 10.1016/j.ejphar.2004.07.038. ISSN: 0014-2999.

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35. Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase. Millan, Mark J.; Newman-Tancredi, Adrian; Duqueyroix, Delphine; Cussac, Didier. European Journal of Pharmacology vol. 424 issue 1 July 13, 2001. p. 13-17

 At h5-HT1A receptors, stably transfected into Chinese Hamster Ovary Cells (CHO-h5-HT1A), the selective… (more)

Keywords: MAPK (Mitogen-activated protein kinase); h5-HT1A receptor; (−)-Pindolol; (+)8-OH-DPAT ((+)8-Hydroxy-dipropyl-amino-tetralin); G protein

ISSN: 0014-2999.

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36. The CRF1 receptor antagonist, DMP695, abolishes activation of locus coeruleus noradrenergic neurones by CRF in anesthetized rats. Lejeune, Françoise; Millan, Mark J. European Journal of Pharmacology vol. 464 issue 2-3 March 19, 2003. p. 127-133

 Corticotropin-releasing factor (CRF)1 receptors have been implicated in the excitatory influence of CRF… (more)

Keywords: Corticotropin-releasing factor (CRF); Locus coeruleus; DMP695; Unit activity

DOI: 10.1016/S0014-2999(03)01383-9. ISSN: 0014-2999.

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37. The Vogel conflict test: procedural aspects, γ-aminobutyric acid, glutamate and monoamines. Millan, Mark J.; Brocco, Mauricette. European Journal of Pharmacology vol. 463 issue 1-3 February 28, 2003. p. 67-96

 A multitude of mechanisms are involved in the control of emotion and in… (more)

Keywords: Anxiety; Anxiolytic; Anxiogenic; Stress; Limbic system; Benzodiazepine; 5-HT1A receptor

DOI: 10.1016/S0014-2999(03)01275-5. ISSN: 0014-2999.

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38. Citalopram elicits a discriminative stimulus in rats at a dose selectively increasing extracellular levels of serotonin vs. dopamine and noradrenaline. Millan, Mark J.; Gobert, Alain; Girardon, Sylvie; Dekeyne, Anne. European Journal of Pharmacology vol. 364 issue 2-3 January 8, 1999. p. 147-150

 Citalopram (2.5 mg/kg, i.p.) increased (+145–+180%) extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in… (more)

Keywords: Drug discrimination; Microdialysis; 5-HT (5-hydroxytryptamine, serotonin) reuptake; Depression; Antidepressant; Selective 5-HT reuptake inhibitor

ISSN: 0014-2999.

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39. The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms. Gannon, Robert L.; Millan, Mark J. European Journal of Pharmacology vol. 527 issue 1-3 December 19, 2005. p. 86-93

 Circadian rhythms in mammals are generated by master pacemaker cells located within the… (more)

Keywords: Circadian; Suprachiasmatic; Neurokinin; Raphe; Depression

DOI: 10.1016/j.ejphar.2005.10.012. ISSN: 0014-2999.

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40. Actions of novel agonists, antagonists and antipsychotic agents at recombinant rat 5-HT6 receptors: A comparative study of coupling to Gαs. Dupuis, Delphine S.; la Cour, Clotilde Mannoury; Chaput, Christine; Verrièle, Laurence; Lavielle, Gilbert; Millan, Mark J. European Journal of Pharmacology vol. 588 issue 2-3 July 7, 2008. p. 170-177

 Though 5-HT6 receptors are targets for the treatment of schizophrenia and other psychiatric… (more)

Keywords: 5-HT6; G-protein; Partial agonist; Antipsychotic; Clozapine; Schizophrenia

DOI: 10.1016/j.ejphar.2008.04.039. ISSN: 0014-2999.

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41. Erratum to “The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortex” [Eur. J. Pharmacol. 489 (2004) 179–185]. Pei, Qi; Sprakes, Marie; Millan, Mark J.; Rochat, Catherine; Sharp, Trevor. European Journal of Pharmacology vol. 495 issue 2-3 July 14, 2004. p. 227-233

 Recent data show that corticolimbic expression of the effector immediate early gene Arc… (more)

Keywords: Antidepressant; Arc (activity-regulated cytoskeletal associated protein); 5-hydroxytryptamine; SNRI (selective 5-HT/noradrenaline reuptake inhibitor); Neuroplasticity

DOI: 10.1016/j.ejphar.2004.05.002. ISSN: 0014-2999.

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42. The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortex. Pei, Qi; Sprakes, Marie; Millan, Mark J.; Rochat, Catherine; Sharp, Trevor. European Journal of Pharmacology vol. 489 issue 3 April 12, 2004. p. 179-185

 Recent data show that corticolimbic expression of the effector immediate early gene Arc… (more)

Keywords: Antidepressant; Arc (activity-regulated cytoskeletal associated protein); 5-hydroxytryptamine; SNRI (selective 5-HT/noradrenaline reuptake inhibitor); Neuroplasticity

DOI: 10.1016/j.ejphar.2004.03.002. ISSN: 0014-2999.

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43. Characterisation of Gs activation by dopamine D1 receptors using an antibody capture assay: antagonist properties of clozapine. Cussac, Didier; Pasteau, Valérie; Millan, Mark J. European Journal of Pharmacology vol. 485 issue 1-3 February 6, 2004. p. 111-117

 Herein, we examined the direct coupling of human dopamine D1 receptors to Gs… (more)

Keywords: Dopamine D1 receptor; Gs protein; Scintillation proximity assay; Clozapine; Haloperidol

DOI: 10.1016/j.ejphar.2003.11.077. ISSN: 0014-2999.

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44. Noradrenaline and adrenaline are high affinity agonists at dopamine D4 receptors. Newman-Tancredi, Adrian; Audinot-Bouchez, Valérie; Gobert, Alain; Millan, Mark J. European Journal of Pharmacology vol. 319 issue 2-3 January 29, 1997. p. 379-383

 The activity of monoamine neurotransmitters was examined at dopamine D4 receptors. In competition… (more)

Keywords: Dopamine D4 receptor; L 745,870; Clozapine; Noradrenaline; Adrenaline; [35S]GTPγS

ISSN: 0014-2999.

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45. Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors. Millan, Mark J.; Perrin-Monneyron, Sabine. European Journal of Pharmacology vol. 321 issue 3 March 5, 1997. p. R11-R13

 The serotonin reuptake inhibitor, fluoxetine (10.0 mg/kg, s.c.), elicited penile erections in rats.… (more)

Keywords: 5-HT2C receptor; Fluoxetine; Antidepressant

ISSN: 0014-2999.

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46. The dopamine D3 receptor antagonist, (+)-S14297, blocks the cataleptic properties of haloperidol in rats. Millan, Mark J.; Gressier, Huguette; Brocco, Mauricette. European Journal of Pharmacology vol. 321 issue 3 March 5, 1997. p. R7-R9

 In contrast to haloperidol, the selective dopamine D3 receptor antagonist, (+)-S 11566 {(±)-[7-(N,N-dipropylamino)-5,6,7,8-tetrahydro-naphtho(2,3b)dihydro,2,3-furane]}… (more)

Keywords: Antipsychotic; Dopamine D3 receptor; Catalepsy

ISSN: 0014-2999.

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47. 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists. Millan, Mark J.; Peglion, Jean-Louis; Lavielle, Gilbert; Perrin-Monneyron, Sabine. European Journal of Pharmacology vol. 325 issue 1 April 23, 1997. p. 9-12

 The mixed 5-HT2A/5-HT2B/5-HT2C receptor agonist, m-(chlorophenyl)piperazine (mCPP), elicited penile erections in rats, an… (more)

Keywords: 5-HT (5-hydroxytryptamine, serotonin); 5-HT2C receptor; Penile erection

ISSN: 0014-2999.

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48. Binding profile of the novel 5-HT1B/1D receptor antagonist, [3H]GR 125,743, in guinea-pig brain: a comparison with [3H]5-carboxamidotryptamine. Audinot, Valérie; Lochon, Sonia; Newman-Tancredi, Adrian; Lavielle, Gilbert; Millan, Mark J. European Journal of Pharmacology vol. 327 issue 2-3 May 30, 1997. p. 247-256

 Native brain 5-HT1B/1D receptors were studied using the novel antagonist, [3H]GR 125,743 (N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-4-(4-pyridyl)benzamide).… (more)

Keywords: 5-HT (5-hydroxytryptamine, serotonin); 5-HT1D receptor; [3H]GR 125,743; [3H]5-CT; (Guinea pig)

ISSN: 0014-2999.

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49. WAY 100,635 enhances both the `antidepressant' actions of duloxetine and its influence on dialysate levels of serotonin in frontal cortex. Millan, Mark J.; Brocco, Mauricette; Veiga, Sylvie; Cistarelli, Laetitia; Melon, Christophe; Gobert, Alain. European Journal of Pharmacology vol. 341 issue 2-3 January 12, 1998. p. 165-167

 The mixed serotonin and noradrenaline reuptake inhibitor, duloxetine, (5.0 mg/kg, s.c.), increased levels… (more)

Keywords: Serotonin reuptake inhibitor; Frontal cortex; Antidepressant; 5-HT1A receptor; 5-HT (5-hydroxytryptamine, serotonin); Depression

ISSN: 0014-2999.

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50. Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPγS binding study. Newman-Tancredi, Adrian; Gavaudan, Samantha; Conte, Caroline; Chaput, Christine; Touzard, Manuelle; Verrièle, Laurence; Audinot, Valerie; Millan, Mark J. European Journal of Pharmacology vol. 355 issue 2-3 August 21, 1998. p. 245-256

 Recombinant human (h) 5-HT1A receptor-mediated G-protein activation was characterised in membranes of transfected… (more)

Keywords: 5-HT1A receptor; [35S]GTPγS binding; Schizophrenia; Clozapine; Ziprasidone; Risperidone

ISSN: 0014-2999.

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51. The 5HT1A receptor ligand, S15535, antagonises G-protein activation: a [35S]GTPγS and [3H]S15535 autoradiography study. Newman-Tancredi, Adrian; Rivet, Jean-Michel; Chaput, Christine; Touzard, Manuelle; Verrièle, Laurence; Millan, Mark J. European Journal of Pharmacology vol. 384 issue 2-3 November 19, 1999. p. 111-121

 4-(Benzodioxan-5-yl)1-(indan-2-yl)piperazine (S15535) is a highly selective ligand at 5-HT1A receptors. The present study… (more)

Keywords: S15535; (+)-8-Hydroxy-dipropyl-aminotetralin; [35S]GTPγS; Autoradiography; 5-HT1A receptor; G-protein

ISSN: 0014-2999.

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52. Blockade of NMDA receptors in the nucleus accumbens elicits spontaneous tail-flicks in rats. Millan, Mark J.; Audinot, Valérie; Honoré, Prisca; Bervoets, Karin; Veiga, Sylvie; Brocco, Mauricette. European Journal of Pharmacology vol. 388 issue 1 January 24, 2000. p. 37-47

 The open channel blocker at N-methyl-d-aspartate (NMDA) receptors, dizocilpine, stereospecifically elicited spontaneous tail-flicks… (more)

Keywords: NMDA receptors; Glutamate; Dizocilpine; Nucleus accumbens; Tail-flick

ISSN: 0014-2999.

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53. Efficacy of antipsychotic agents at human 5-HT1A receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation. Newman-Tancredi, Adrian; Verrièle, Laurence; Touzard, Manuelle; Millan, Mark J. European Journal of Pharmacology vol. 428 issue 2 October 5, 2001. p. 177-184

 5-HT1A receptors are implicated in the aetiology of schizophrenia. Herein, the influence of… (more)

Keywords: 5-HT1A receptor; WAY100,635; Inverse agonist; Clozapine; S16924; Antipsychotic

ISSN: 0014-2999.

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54. The novel antagonist, S33084, and GR218,231 interact selectively with cloned and native, rat dopamine D3 receptors as compared with native, rat dopamine D2 receptors. Cussac, Didier; Newman-Tancredi, Adrian; Sezgin, Lucie; Millan, Mark J. European Journal of Pharmacology vol. 394 issue 1 April 7, 2000. p. 47-50

 The novel benzopyranopyrrole, S33084 ((3aR,9bS)-N[4-(8-cyano-1,3a,4,9b-tetrahydro-3H-benzopyrano[3,4-c]pyrrole-2-yl)-butyl] (4-phenyl)benzamide)), and the aminotetralin derivative, GR218,231 (2(R,S)-(di-n-propylamino)-6-(4-methoxyphenylsulfonylmethyl)-1,2,3,4-tetrahydro naphthalene),… (more)

Keywords: Dopamine D3 receptor; Limbic system

ISSN: 0014-2999.

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55. Selective blockade of neurokinin (NK)1 receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats. Millan, Mark J.; Lejeune, Françoise; De Nanteuil, Guillaume; Gobert, Alain. Journal of Neurochemistry vol. 76 issue 6 March 15, 2001. p. 1949-1954

  The selective NK1 receptor antagonist, GR205,171 (2.5–40.0 mg/kg, i.p.), dose-dependently elevated dialysate levels… (more)

Keywords: antidepressant; frontal cortex; locus coeruleus; neurokinin1; noradrenaline; substance P

DOI: 10.1046/j.1471-4159.2001.00211.x. ISSN: 0022-3042.

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56. Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole. Maggio, Roberto; Scarselli, Marco; Novi, Francesca; Millan, Mark J.; Corsini, Giovanni U. Journal of Neurochemistry vol. 87 issue 3 November 2003. p. 631-641

  Abstract Recombinant, human dopamine D3 and D2 receptors form functional heterodimers upon… (more)

Keywords: adenylyl cyclase; antiparkinson; chimera; dopamine D3 receptor; dopamine D2 receptor; heterodimer; Parkinson's disease

DOI: 10.1046/j.1471-4159.2003.02038.x. ISSN: 0022-3042.

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57. Influence of positive allosteric modulators on GABAB receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes. Mannoury la Cour, Clotilde; Herbelles, Chloé; Pasteau, Valérie; de Nanteuil, Guillaume; Millan, Mark J. Journal of Neurochemistry vol. 105 issue 2 April 2008. p. 308-323

  Abstract Little is known concerning coupling of cerebral GABAB receptors to G… (more)

Keywords: allosteric modulator; cerebellum; cortex; G protein; GABAB receptors; hippocampus; scintillation proximity assay

DOI: 10.1111/jnc.2008.105.issue-2. ISSN: 0022-3042.

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58. Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D2L receptors are modified by co-transfection of D3 receptors: potential role of heterodimer formation. Novi, Francesca; Millan, Mark J.; Corsini, Giovanni U.; Maggio, Roberto. Journal of Neurochemistry vol. 102 issue 4 August 2007. p. 1410-1424

  Abstract Aripiprazole and the candidate antipsychotics, S33592, bifeprunox, N-desmethylclozapine (NDMC) and preclamol,… (more)

Keywords: adenylate cyclase; antipsychotic; chimera; dopamine D2 receptors; dopamine D3 receptors; heterodimers

DOI: 10.1111/j.1471-4159.2007.04660.x. ISSN: 0022-3042.

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59. Selective blockade of dopamine D3 versus D2 receptors enhances frontocortical cholinergic transmission and social memory in rats: a parallel neurochemical and behavioural analysis. Millan, Mark J.; Di Cara, Benjamin; Dekeyne, Anne; Panayi, Fany; De Groote, Lotte; Sicard, Dorothée; Cistarelli, Laetitia; Billiras, Rodolphe; Gobert, Alain. Journal of Neurochemistry vol. 100 issue 4 February 2007. p. 1047-1061

  Abstract Though dopaminergic mechanisms modulate cholinergic transmission and cognitive function, the significance… (more)

Keywords: acetylcholine; dialysis; dopamine; dopaminez-receptors; frontal cortex; social memory

DOI: 10.1111/j.1471-4159.2006.04262.x. ISSN: 0022-3042.

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60. Improvement in the Selectivity and Metabolic Stability of the Serotonin 5-HT1A Ligand, S 15535:  A Series of cis- and trans-2-(Arylcycloalkylamine) 1-Indanols. Peglion, Jean-Louis; Goument, Bertr; Despaux, Nicole; Charlot, Valérie; Giraud, Hélène; Nisole, Christian; Newman-Tancredi, Adrian; Dekeyne, Anne; Bertr, Marc; Genissel, Patrick; Millan, Mark J. Journal of Medicinal Chemistry vol. 45 issue 1 January 03, 2002. p. 165-176

DOI: http://dx.doi.org/10.1021/jm010975+. ISSN: 0022-2623.

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