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64 matches in the database. These are records: 1 - 30. New search.

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1. ChemInform Abstract: Ring-Closing Metathesis for the Synthesis of a Highly G-Quadruplex Selective Macrocyclic Hexaoxazole Having Enhanced Cytotoxic Potency. Satyanarayana, Mavurapu; Rzuczek, Suzanne G.; LaVoie, Edmond J.; Pilch, Daniel S.; Liu, Angela; Liu, Leroy F.; Rice, Joseph E. ChemInform vol. 39 issue 46 November 11, 2008.

 ChemInform is a weekly Abstracting Service, delivering concise information at a glance that… (more)

Keywords: multi-membered O,N,S-heterocycles (with at least 2 different heteroatoms); metathesis reactions; anticarcinogenic activity, anticancer activity; oxazole derivatives

DOI: 10.1002/chin.200846180. ISSN: 0931-7597.

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2. Plasmid linking number change induced by topoisomerase I-mediated DNA damage. Duann, Pu; Sun, Mei; Lin, Chin-Tai; Zhang, Hui; Liu, Leroy F.; Mathis, G.; Wang, Z.G.; Gaillard, P.H.; et al. Nucleic Acids Research vol. 27 issue 14 July 1999. p. 2905-2911

 The state of cellular chromatin in response to DNA damage has been examined… (more)

ISSN: 0305-1048.

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3. Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. Haluska, Paul; Saleem, Ahamed; Rasheed, Zeshaan; Ahmed, Farheena; Su, Emily W.; Liu, Leroy F.; Rubin, Eric H.; Liu, L.F.; et al. Nucleic Acids Research vol. 27 issue 12 June 1999. p. 2538-2544

 The N-terminus of human topoisomerase I participates in the binding of this enzyme… (more)

ISSN: 0305-1048.

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4. Involvement of Amino Acids 361 to 364 of Human Topoisomerase I in Camptothecin Resistance and Enzyme Catalysis. Li, Xi-Guang; Haluska Jr, Paul; Hsiang, Yaw-Huei; Bharti, Ajit K.; Kufe, Donald W.; Liu, Leroy F.; Rubin, Eric H. Biochemical Pharmacology vol. 53 issue 7 April 4, 1997. p. 1019-1027

 Camptothecins are antineoplastic drugs that specifically target the enzyme DNA topoisomerase I. Prior… (more)

Keywords: topoisomerase; camptothecin; DNA binding; DNA cleavage; drug resistance; enzyme mutations

ISSN: 0006-2952.

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5. Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells. Sanders, Marilyn M.; Liu, Angela A.; Li, Tsai-Kun; Wu, Hong-Yan; Desai, Shyamal D.; Mao, Yong; Rubin, Eric H.; LaVoie, Edmond J.; Makhey, Darshan; Liu, Leroy F. Biochemical Pharmacology vol. 56 issue 9 November 1, 1998. p. 1157-1166

 Protoberberines are a new class of organic cations that are dual poisons of… (more)

Keywords: DNA topoisomerase poison; biological transport; selective cytotoxicity; tumor cells, cultured; antineoplastic agents; berberines

ISSN: 0006-2952.

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6. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Ting, Chun-Yuan; Hsu, Chia-Tse; Hsu, Hsiang-Ting; Su, Jin-Shan; Chen, Tzong-Yueh; Tarn, Woan-Yuh; Kuo, Yao-Haur; Whang-Peng, Jacqueline; Liu, Leroy F.; Hwang, Jaulang. Biochemical Pharmacology vol. 66 issue 10 November 15, 2003. p. 1981-1991

 Isodiospyrin is a natural product from the plant Diospyros morrisiana, which consists of… (more)

Keywords: htopo I; human topoisomerase I; CPT; camptothecin; m-AMSA; (N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulphonanilide); SRPK1; SR protein kinase-1; ATP; adenosine triphosphate; SF2/ASF; splicing factor 2/alternate splicing factor; Isodiospyrin; Camptothecin; Human DNA topoisomerase I; Diospyros morrisiana; Kinase; Binaphthoquinone

DOI: 10.1016/j.bcp.2003.07.003. ISSN: 0006-2952.

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7. Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31). Satyanarayana, Mavurapu; Feng, Wei; Cheng, Liang; Liu, Angela A.; Tsai, Yuan-Chin; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 16 issue 16 August 15, 2008. p. 7824-7831

 Several 11-ethyl-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-ones with varied functionality on the ethyl substituent have exhibited potent topoisomerase… (more)

Keywords: Topoisomerase; Cinnolines; Isoquino[4,3-c]cinnolin-12-ones; Cytotoxicity; Antitumor; Multidrug resistance; Athymic mice; Human tumor xenografts

DOI: 10.1016/j.bmc.2008.06.046. ISSN: 0968-0896.

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8. 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity. Zhu, Shejin; Ruchelman, Alexander L.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 14 issue 9 May 1, 2006. p. 3131-3143

 6-Substituted 8,9-dimethoxy-2,3-methylenedioxy-6H-dibenzo[c,h][2,6]naphthyridin-5-ones were synthesized and evaluated for topoisomerase I-targeting activity and cytotoxicity. Several… (more)

Keywords: Topoisomerase I; Cytotoxic; Antitumor; Dibenzo[c,h][2,6]naphthyridin-5-ones

DOI: 10.1016/j.bmc.2005.12.028. ISSN: 0968-0896.

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9. Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents. Zhu, Shejin; Ruchelman, Alexander L.; Zhou, Nai; Liu, Angela A.; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 13 issue 24 December 15, 2005. p. 6782-6794

 The exceptional topoisomerase I-targeting activity and antitumor activity of 5-(2-N,N-dimethylamino)ethyl-8,9-dimethoxy-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one (ARC-111, topovale) prompted… (more)

Keywords: Topoisomerase I; Cytotoxic; Antitumor; Benzo[i]phenanthridine

DOI: 10.1016/j.bmc.2005.07.033. ISSN: 0968-0896.

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10. Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity. Bacherikov, Valeriy A.; Chou, Ting-Chao; Dong, Hua-Jin; Zhang, Xiuguo; Chen, Ching-Huang; Lin, Yi-Wen; Tsai, Tsong-Jen; Lee, Rong-Zau; Liu, Leroy F.; Su, Tsann-Long. Bioorganic & Medicinal Chemistry vol. 13 issue 12 June 2, 2005. p. 3993-4006

 A series of N-mustard derivatives of 9-anilinoacridine was synthesized for antitumor and structure–activity… (more)

Keywords: Acridines; Antitumour compounds; Alkylating agents; Synthesis; Chemotherapy

DOI: 10.1016/j.bmc.2005.03.057. ISSN: 0968-0896.

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11. Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity. Ruchelman, Alexander L.; Kerrigan, John E.; Li, Tsai-Kun; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 12 issue 13 July 1, 2004. p. 3731-3742

 Recently, 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxydibenzo[c,h][1,6]naphthyridin-6-one, 1, was identified as a TOP1-targeting agent with pronounced antitumor activity.… (more)

DOI: 10.1016/j.bmc.2004.03.076. ISSN: 0968-0896.

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12. Structure-Activity Relationships of Benzimidazoles and Related Heterocycles as Topoisomerase I Poisons. Jung, Sun Kim; Qun, Sun; Gatto, Barbara; Chiang, Yu; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 4 issue 4 April, 1996. p. 621-630

 A series of substituted 2-(4-methoxyphenyl)-1H-benzimidazoles were synthesized and evaluated as inhibitors of topoisomerase… (more)

ISSN: 0968-0896.

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13. Coralyne and Related Compounds as Mammalian Topoisomerase I and Topoisomerase II Poisons. Makhey, Darshan; Gatto, Barbara; Chiang, Yu; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 4 issue 6 June, 1996. p. 781-791

 DNA topoisomerases are nuclear enzymes responsible for modifying the topological state of DNA.… (more)

ISSN: 0968-0896.

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14. 11H-Isoquino[4,3-c]cinnolin-12-ones. Ruchelman, Alexander L.; Singh, Sudhir K.; Ray, Abhijit; Wu, Xiaohua; Yang, Jin-Ming; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 12 issue 4 February 15, 2004. p. 795-806

 Recent studies have identified 2,3-dimethoxy-8,9-methylenedioxy-11-[(2-dimethylamino)ethyl]-11H-isoquino[4,3-c]cinnolin-12-one (1a) as a novel topoisomerase I-targeting agent with… (more)

DOI: 10.1016/j.bmc.2003.10.061. ISSN: 0968-0896.

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15. Quantitative structure–activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents. Kim, Jung Sun; Sun, Qun; Yu, Chiang; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 6 issue 2 February 1, 1998. p. 163-172

 Several 5-substituted terbenzimidazoles were synthesized and evaluated as mammalian topoisomerase I poisons and… (more)

Keywords: Antitumor; QSAR; structure–activity; topoisomerase; terbenzimidazoles

ISSN: 0968-0896.

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16. Topoisomerase I inhibition and cytotoxicity of 5-Bromo- and 5-Phenylterbenzimidazoles. Rangarajan, Meera; Kim, Jung Sun; Sim, Sai-Peng; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 8 issue 11 November, 2000. p. 2591-2600

 Topoisomerase I is an enzyme that is essential for maintaining the three-dimensional structure… (more)

ISSN: 0968-0896.

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17. 8,9-Methylenedioxybenzo[i]phenanthridines. Li, Dajie; Zhao, Baoping; Sim, Sai-Peng; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 11 issue 17 August 15, 2003. p. 3795-3805

 Substituted benzo[i]phenanthridines that have incorporated within their structure an 8,9-methylenedioxy group can exhibit… (more)

DOI: 10.1016/S0968-0896(03)00394-8. ISSN: 0968-0896.

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18. 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-Targeting anticancer agents with potent cytotoxic activity. Ruchelman, Alexander L.; Singh, Sudhir K.; Ray, Abhijit; Wu, Xiao Hua; Yang, Jin-Ming; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 11 issue 9 May 1, 2003. p. 2061-2073

 5H-Dibenzo[c,h]1,6-naphthyridine-6-ones can exhibit potent antitumor activity. The effect of varied substituents at the… (more)

DOI: 10.1016/S0968-0896(03)00051-8. ISSN: 0968-0896.

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19. Substituted benzo[i]phenanthridines as mammalian topoisomerase-Targeting agents. Makhey, Darshan; Li, Dajie; Zhao, Baoping; Sim, Sai-Peng; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 11 issue 8 April, 2003. p. 1809-1820

 Several benzo[c]phenanthridine and protoberberine alkaloids, such as nitidine and berberrubine, are known to… (more)

DOI: 10.1016/S0968-0896(03)00053-1. ISSN: 0968-0896.

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20. Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents. Yu, Younong; Singh, Sudhir K.; Liu, Angela; Li, Tsai-Kun; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 11 issue 7 April, 2003. p. 1475-1491

 Several substituted dibenzo[c,h]cinnolines were synthesized and evaluated for their potential to target topoisomerase… (more)

DOI: 10.1016/S0968-0896(02)00604-1. ISSN: 0968-0896.

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21. 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. Li, Dajie; Zhao, Baoping; Sim, Sai-Peng; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 11 issue 4 February 20, 2003. p. 521-528

 Appropriately substituted benzo[i]phenanthridines structurally related to nitidine, a benzo[c]phenanthridine alkaloid with antitumor activity,… (more)

ISSN: 0968-0896.

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22. Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons. Makhey, Darshan; Yu, Chiang; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry vol. 8 issue 5 May, 2000. p. 1171-1182

 Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited… (more)

ISSN: 0968-0896.

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23. 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. Feng, Wei; Satyanarayana, Mavurapu; Tsai, Yuan-Chin; Liu, Angela A.; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 17 issue 7 April 1, 2009. p. 2877-2885

 2,3-Dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine and a few of its 12-substituted analogs are active as TOP1-targeting agents.… (more)

Keywords: Topoisomerase I; Cytotoxicity; Benzo[i]phenanthridines; Structure–activity

DOI: 10.1016/j.bmc.2009.02.023. ISSN: 0968-0896.

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24. Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates. Feng, Wei; Satyanarayana, Mavurapu; Tsai, Yuan-chin; Liu, Angela A.; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry Letters vol. 18 issue 12 June 15, 2008. p. 3570-3572

 Several new TOP1-targeting agents were prepared using as intermediates the N,N,N-trimethyl quaternary ammonium… (more)

Keywords: Topoisomerase I; Antitumor; Quaternary ammonium salts; Cytotoxicity; Dibenzo[c,h][1,6]naphthyridin-6-ones; Isoquino[4,3-c]cinnoline-12-ones; ARC-111; ARC-31

DOI: 10.1016/j.bmcl.2008.05.005. ISSN: 0960-894X.

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25. Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency. Satyanarayana, Mavurapu; Rzuczek, Suzanne G.; LaVoie, Edmond J.; Pilch, Daniel S.; Liu, Angela; Liu, Leroy F.; Rice, Joseph E. Bioorganic & Medicinal Chemistry Letters vol. 18 issue 13 July 1, 2008. p. 3802-3804

 The synthesis of a 24-membered macrocyclic hexaoxazole via ring-closing metathesis is described. The… (more)

Keywords: Synthesis; Macrocycle; Hexaoxazole; Cytotoxic; G-quadruplex stabilizer; Ring-closing metathesis; Selective

DOI: 10.1016/j.bmcl.2008.05.032. ISSN: 0960-894X.

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26. Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435. Ruchelman, Alexander L.; Singh, Sudhir K.; Wu, Xiaohua; Ray, Abhijit; Yang, Jin-Ming; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry Letters vol. 12 issue 22 November 18, 2002. p. 3333-3336

 Several 5,12-diazachrysen-6-ones and 5,6,11-triazachrysen-12-ones were synthesized with varied substituents at the 5- or… (more)

ISSN: 0960-894X.

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27. Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity. Ruchelman, Alexander L.; Zhu, Shejin; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry Letters vol. 14 issue 22 November 15, 2004. p. 5585-5589

 The exceptional TOP1-targeting activity and antitumor activity of ARC-111, 1, prompted studies on… (more)

Keywords: Topoisomerase I; Cytotoxic agents; Anticancer; Benzo[i]phenanthridines; Dibenzo[c,h]naphthyridines

DOI: 10.1016/j.bmcl.2004.08.070. ISSN: 0960-894X.

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28. Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity. Satyanarayana, Mavurapu; Kim, Young-Ah; Rzuczek, Suzanne G.; Pilch, Daniel S.; Liu, Angela A.; Liu, Leroy F.; Rice, Joseph E.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry Letters vol. 20 issue 10 May 15, 2010. p. 3150-3154

 A series of 24-membered macrocyclic hexaoxazoles containing one or two aminoalkyl substituents was… (more)

Keywords: G-quadruplex DNA; G-quadruplex RNA; Macrocycles; Hexaoxazoles; Antitumor; MDA-MB-435 xenograft; Cytotoxicity; Athymic nude mice; G-quadruplex ligands

DOI: 10.1016/j.bmcl.2010.03.086. ISSN: 0960-894X.

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29. Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents. Feng, Wei; Satyanarayana, Mavurapu; Cheng, Liang; Liu, Angela; Tsai, Yuan-Chin; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 16 issue 20 October 15, 2008. p. 9295-9301

 Several N-alkyl and N,N-dialkyl 5H-8,9-dimethoxy-5-(2-aminoethyl)-2,3-methylenedioxydibenzo[c,h][1,6]naphthyridin-6-ones have been identified as topoisomerase I-targeting agents with… (more)

Keywords: Topoisomerase I; Cytotoxicity; Antitumor; MDA-MB-435; Structure–activity; Non-camptothecin

DOI: 10.1016/j.bmc.2008.09.002. ISSN: 0968-0896.

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30. 11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents. Feng, Wei; Satyanarayana, Mavurapu; Tsai, Yuan-Chin; Liu, Angela A.; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic & Medicinal Chemistry vol. 16 issue 18 September 15, 2008. p. 8598-8606

 Several 11-substituted benzo[i]phenanthridine derivatives were synthesized, and their TOP1-targeting activity and cytotoxicity were… (more)

Keywords: Cytotoxicity; Antitumor agents; Topoisomerase I; Benzo[i]phenanthridines; Multidrug resistance; Photocyclization

DOI: 10.1016/j.bmc.2008.08.018. ISSN: 0968-0896.

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